Why the study?
While the primary endpoint for sepsis trials is 28-day mortality, additional methods for determining efficacy may be beneficial, prompting a search for a useful indicator of anticoagulant therapy in sepsis-associated DIC.
Does the change in SOFA score from baseline to day 7 predict 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation?
Population
323 patients with sepsis with coagulopathy treated with antithrombin supplementation
Comparison
Changes in SOFA score vs overt-DIC score vs JAAM DIC score from baseline to day 7
Design
Retrospective analysis
Follow-up
28 days
Authors
Loading...
ΔSOFA or Δovert-DIC may indicate antithrombin response in sepsis-DIC; leaves open prospective validation before clinical use.
Does the change in SOFA score from baseline to day 7 predict 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation?
Changes in the SOFA score from baseline to day 7 are a strong predictor of 28-day mortality in patients with sepsis and disseminated intravascular coagulation.
Iba et al. (2019) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: