Population
Dogs following ligation of left anterior descending coronary artery
Design
Preclinical
Follow-up
7 days
Authors
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Caution against extrapolating canine post-MI shock vulnerability to humans; leaves open temporal effects on arrhythmia thresholds for future study.
In a canine model of myocardial infarction, low energy shocks during the vulnerable period induce ventricular tachycardia that degenerates to fibrillation, but this vulnerability resolves within 7 days.
Wolff et al. (1968) studied this question.
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