What question did this study set out to answer?

To review evidence on whether steady-state lymphocyte formation in adult tissues recapitulates fetal ontogeny and to evaluate the influence of developmental timing on lymphoid differentiation.

September 1, 2002Immunological Reviews

Nature or nurture? Steady‐state lymphocyte formation in adults does not recapitulate ontogeny

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Authors

PKPaul W. Kincade JOJohn J. T. Owen HIHideya Igarashi

Discussion

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Overview

Literature review demonstrates distinct lymphocyte differentiation pathways across developmental stages, suggesting adult blood cell formation originates independently of fetal stem cell programs.

Key Points

To review evidence on whether steady-state lymphocyte formation in adult tissues recapitulates fetal ontogeny and to evaluate the influence of developmental timing on lymphoid differentiation.
Reviewed lineage-tracing and differentiation models, including RAG1/GFP knock-in mouse studies in adult bone marrow and thymus.
Analyzed gene targeting experiments and cellular transplantation models comparing fetal versus adult hematopoietic stem and progenitor cell behaviors.
Gene expression profiles and functional properties of lymphocyte precursors change substantially with developmental age, requiring several weeks after birth to reach mature adult patterns in mice.
Fetal hematopoietic cells fail to efficiently adopt adult-like properties when transplanted directly into adult recipient environments.
Hematopoietic stem cells and lymphoid precursors emerge in discrete developmental waves, suggesting adult stem cells may arise from distinct founder origins rather than direct fetal continuity.

Cite This Study

Kincade et al. (2002) studied this question.

synapsesocial.com/papers/6a70c342febe604dd709866b https://doi.org/10.1034/j.1600-065x.2002.18710.x

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September 1, 2002Immunological Reviews

Nature or nurture? Steady‐state lymphocyte formation in adults does not recapitulate ontogeny

View Full Paper

Ask AI

Bookmark

Authors

PKPaul W. Kincade JOJohn J. T. Owen HIHideya Igarashi

Discussion

Member takes

Overview

Literature review demonstrates distinct lymphocyte differentiation pathways across developmental stages, suggesting adult blood cell formation originates independently of fetal stem cell programs.

Key Points

To review evidence on whether steady-state lymphocyte formation in adult tissues recapitulates fetal ontogeny and to evaluate the influence of developmental timing on lymphoid differentiation.
Reviewed lineage-tracing and differentiation models, including RAG1/GFP knock-in mouse studies in adult bone marrow and thymus.
Analyzed gene targeting experiments and cellular transplantation models comparing fetal versus adult hematopoietic stem and progenitor cell behaviors.
Gene expression profiles and functional properties of lymphocyte precursors change substantially with developmental age, requiring several weeks after birth to reach mature adult patterns in mice.
Fetal hematopoietic cells fail to efficiently adopt adult-like properties when transplanted directly into adult recipient environments.
Hematopoietic stem cells and lymphoid precursors emerge in discrete developmental waves, suggesting adult stem cells may arise from distinct founder origins rather than direct fetal continuity.

Cite This Study

Kincade et al. (2002) studied this question.

synapsesocial.com/papers/6a70c342febe604dd709866b https://doi.org/10.1034/j.1600-065x.2002.18710.x

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