Hypoglycemia, Hyperglycemia, and Gatifloxacin

Letters21 December 2004Hypoglycemia, Hyperglycemia, and GatifloxacinWeerapan Khovidhunkit, MD, PhD and Sarat Sunthornyothin, MDWeerapan Khovidhunkit, MD, PhDFrom Chulalongkorn University, Bangkok, Thailand 10330. and Sarat Sunthornyothin, MDFrom Chulalongkorn University, Bangkok, Thailand 10330.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-12-200412210-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Gatifloxacin is being widely used to treat a variety of infections. Recently, concerns have been raised about the effect of gatifloxacin on glucose metabolism (1-3).Objective: To describe cases of gatifloxacin use associated with 1) hypoglycemia in a patient with preexisting diabetes mellitus and 2) hyperglycemia in another patient with no history of diabetes.Case Reports: Patient 1, an 87-year-old woman with type 2 diabetes mellitus, hypertension, and coronary artery disease, was admitted to the hospital for pneumonia. The patient's medications at admission consisted of glibenclamide, 7.5 mg/d; insulin, 10 units every evening; aspirin; trimetazidine; dextromethorphan; ...References1. Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH. Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents. Am J Med. 2002;113:232-4. [PMID: 12208383] CrossrefMedlineGoogle Scholar2. Donaldson AR, Vandiver JR, Finch CK. Possible gatifloxacin-induced hyperglycemia. Ann Pharmacother. 2004;38:602-5. [PMID: 14982977] CrossrefMedlineGoogle Scholar3. Summary of Safety-Related Drug Labeling Changes Approved by FDA Center for Drug Evaluation and Research (CDER). October 2002. Accessed at www.fda.gov/medwatch/SAFETY/2002/oct02.htm. Google Scholar Author, Article, and Disclosure InformationAuthors: Weerapan Khovidhunkit, MD, PhD; Sarat Sunthornyothin, MDAffiliations: From Chulalongkorn University, Bangkok, Thailand 10330. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGatifloxacinQuinolonesANTIBACTERIAL DRUGSHypoglycemia associated with the use of levofloxacinENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSGatifloxacin Produces Both Hypoglycemia and Hyperglycemia: A Retrospective StudyRisk factors for hyperglycemia in hospitalized adults receiving gatifloxacin: A retrospective, nested case-controlled analysisAn Open Randomized Comparison of Gatifloxacin versus Cefixime for the Treatment of Uncomplicated Enteric FeverGatifloxacin-Induced Hyperglycemia: A Review of 4 Cases and the Literature26 Miscellaneous antibacterial drugsGatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesisGatifloxacin-induced hyperglycemia: A case report and summary of the current literatureGatifloxacin-induced dysglycemiaComparison of the adverse event profiles of levofloxacin 500 mg and 750 mg in clinical trials for the treatment of respiratory infectionsOutpatient Gatifloxacin Therapy and Dysglycemia in Older AdultsHyperglycemia in an Elderly Diabetic Patient: Drug-drug or Drug-disease Interaction?Effects of Gatifloxacin on Serum Glucose Concentration in Normal and Diabetic RatsHyperglycemia and gatifloxacin: A case report and summary of current literatureA Retrospective, Comparative Evaluation of Dysglycemias in Hospitalized Patients Receiving Gatifloxacin, Levofloxacin, Ciprofloxacin, or CeftriaxoneCurrent awareness: Pharmacoepidemiology and drug safetyPulmonary Hypertension with Thalidomide Therapy; Hyperammonemia and Valproate; CNS Toxicity from Improper Use of Cyclopentolate Ophthalmic Drops; Glycemic Control Issues with Gatifloxacin; Infusion Phlebitis with Cyclosporine; Acute Hypersensitivity Reaction to HIV Fusion Inhibitor; Imatinib-Induced Hepatotoxicity 21 December 2004Volume 141, Issue 12Page: 969KeywordsBloodBlood plasmaDiabetes mellitusGlucoseHyperglycemiaHypertensionHypoglycemiaInsulinInsulin secretionProtamines ePublished: 21 December 2004 Issue Published: 21 December 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...