49 pages with 49 color figures and 18 page index Skeletal examination, in addition to external and visceral examinations, is one of the major components for detection of developmental anomalies in term fetuses in the studies of administration at the organogenetic period (so called teratogenicity or embryotoxicity study, former segment I1 study in pharmaceutical drugs and study for effects in embryo-fetal development in the new ICH guidelines). This is due to the fact that skeletal anomalies with clinical significance in human teratology have been abundantly induced by teratogens and they are relatively easily detected by specific staining procedures.
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Yasuda et al. (1996) studied this question.
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