Why the study?
Data on temporal trends in guideline-based medical and device therapies in real-world chronic heart failure patients are lacking.
How have the use of guideline-directed medical and device therapies and the rates of one-year mortality and rehospitalization changed over time in incident heart failure patients?
Population
291,720 incident HF patients in Denmark during 1996-2019
Comparison
Temporal trends across 1996-2019
Design
Nationwide register-based follow-up study
Follow-up
One-year
Authors
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Increasing GDMT and device use coincided with lower one-year mortality and rehospitalizations; leaves open whether trends reflect causation or apply outside Denmark.
How have the use of guideline-directed medical and device therapies and the rates of one-year mortality and rehospitalization changed over time in incident heart failure patients?
Over a 24-year period in Denmark, increased utilization of guideline-directed medical therapies for heart failure was associated with significant reductions in one-year all-cause mortality and HF rehospitalizations, though newer therapies like ARNI and SGLT2i remain underutilized.
Ettrup-Christensen et al. (2023) studied this question.
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