Why the study?
Does DWORF directly activate SERCA and improve calcium reuptake in the absence of phospholamban in in vitro and cell models?
Design
In vitro and molecular dynamics simulation study
Authors
Loading...
No immediate clinical implications for heart failure; leaves open DWORF as a research target for SERCA modulation.
Does DWORF directly activate SERCA and improve calcium reuptake in the absence of phospholamban in in vitro and cell models?
DWORF is a direct activator of SERCA that increases its maximal turnover rate and cellular calcium reuptake even in the absence of phospholamban, providing a potential novel mechanism for modulating cardiac calcium handling.
Fisher et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: