What question did this study set out to answer?

To determine whether chronic beta-adrenergic blockade compromises the cardiovascular and aerobic benefits of exercise training in patients with coronary artery disease.

December 1, 1981Circulation

Demonstration of training effect during chronic beta-adrenergic blockade in patients with coronary artery disease.

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Why the study?

Does exercise training improve VO2 max in CAD patients receiving chronic beta-blocker therapy compared to those not receiving beta-blockers?

Population

35 patients with coronary artery disease (CAD)

Comparison

3-month walk-jog-cycle training program while… vs Same 3-month training program with no beta…

Design

Cohort

Follow-up

3 months

Authors

CPCraig M. PrattUniversity of California, Davis DWDavid E. WeltonBaylor College of Medicine WSW. G. SquiresThe University of Texas of the Permian Basin

Discussion

Member takes

Implication

Supports aerobic training in CAD patients on beta-blockers; leaves open prospective validation of dose-independent benefits.

Key Points

To determine whether chronic beta-adrenergic blockade compromises the cardiovascular and aerobic benefits of exercise training in patients with coronary artery disease.
Assessed 35 patients with coronary artery disease across three treatment groups: no beta blocker (group 1, n=14), low-to-moderate propranolol (30-80 mg/day; group 2, n=14), and high-dose propranolol (120-240 mg/day; group 3, n=7).
Administered a 3-month walk-jog-cycle training program consisting of three 1-hour sessions per week at 70% to 85% of maximal pretraining heart rate.
Maximal exercise heart rate before training was significantly lower in beta-blocker groups (147 ± 21 beats/min in group 1 vs 120 ± 10 in group 2 and 115 ± 12 in group 3; p < 0.05 vs group 1).
Maximal oxygen uptake (VO2 max) increased significantly in all groups after training: 27% in group 1, 30% in group 2, and 46% in group 3 (p < 0.05 for all groups), with no change in double product.

Structured PICO

Does exercise training improve VO2 max in CAD patients receiving chronic beta-blocker therapy compared to those not receiving beta-blockers?

Population

35 patients with coronary artery disease (CAD)

Intervention

3-month walk-jog-cycle training program (three 1-hour periods per week at 70-85% of maximal pretraining heart rate) while receiving propranolol 30-80 mg/day (n=14) or 120-240 mg/day (n=7)

Comparator

Same 3-month training program with no beta blocker therapy (n=14)

Outcome

Change in VO2 max after 3 months of trainingsurrogate

Exercise training yields substantial improvements in exercise capacity (VO2 max) in CAD patients regardless of concurrent beta-blocker therapy, suggesting no need to reduce beta-blocker doses during cardiac rehabilitation.

Cite This Study

Pratt et al. (1981) studied this question.

synapsesocial.com/papers/6a70c71de5469ee92be174ef https://doi.org/10.1161/01.cir.64.6.1125

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Demonstration of training effect during chronic beta-adrenergic blockade in patients with coronary artery disease.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Demonstration of training effect during chronic beta-adrenergic blockade in patients with coronary artery disease.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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