Why the study?
To investigate the diagnostic value of different captopril challenge test diagnostic criteria for diagnosing primary aldosteronism.
Does the captopril challenge test accurately diagnose primary aldosteronism in patients with hypertension?
Does the captopril challenge test accurately diagnose primary aldosteronism in patients with hypertension?
Post-CCT plasma aldosterone concentration (PAC) and aldosterone renin activity ratio (ARR) have high diagnostic value and are suitable as confirmatory testing criteria for primary aldosteronism.
OBJECTIVE: To investigate the diagnostic value of different captopril challenge test (CCT) diagnostic criteria for diagnosing primary aldosteronism (PA). METHODS: We collected the clinical data of 184 patients with hypertension retrospectively in West China Hospital of Sichuan University. Receiver operating characteristic (ROC) curves were used to analyze the post-CCT efficacy of aldosterone renin activity ratio (ARR), plasma aldosterone concentration (PAC), plasma renin activity (PRA) and PAC suppression rate for PA diagnosis. RESULTS: ) with a sensitivity of 84.17% and a specificity of 72.41%. CONCLUSION: Both ARR and PAC have higher diagnostic value than the post-CCT PAC suppression rate, post-CCT PAC is especially suitable as a confirmatory testing criterion of PA.
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Chen et al. (2021) studied this question.
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