Why the study?
Contrary to reports that antiplatelet agents inhibit cancer growth, new solid tumors have been reported with long-term therapy, prompting investigation into direct effects on cancer cells without platelets.
Do antiplatelet agents affect colon cancer cell motility and metastasis potential?
Population
Colon cancer cells and serum from patients who received antiplatelet drugs
Comparison
Treatment with antiplatelet agents (aspirin, clopidogrel, prasugrel, ticagrelor) vs control
Design
In vitro and translational laboratory study
Authors
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Questions discrepant clinical reports of new tumors; leaves open relevance of direct in vitro effects to long-term therapy.
Do antiplatelet agents affect colon cancer cell motility and metastasis potential?
P2Y12 inhibitors may paradoxically increase colon cancer cell motility and metastatic potential via the SERPINE1/MMP1 pathway.
Kim et al. (2022) studied this question.
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