Why the study?
Does optimal medical therapy (OMT) reduce 1-year mortality in patients with acute myocardial infarction?
Population
5353 patients with acute myocardial infarction
Comparison
Optimal medical therapy consisting of a… vs Patients receiving one or no drug
Design
Cohort
Follow-up
1 year
Authors
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OMT was associated with lower post-AMI mortality; hypothesis-generating and requires RCTs before changing practice.
Does optimal medical therapy (OMT) reduce 1-year mortality in patients with acute myocardial infarction?
Optimal medical therapy (combining 5 drug classes) significantly reduces 1-year mortality after acute myocardial infarction in clinical practice, though it is underutilized.
Bramlage et al. (2010) studied this question.
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