Postexercise ketone monoester administration concomitant with glucose stimulates glycogen repletion in soleus muscle in mice

This is the first study to compare the effects of postexercise ketone body intake on glycogen repletion in fast-twitch fiber- and slow-twitch fiber-dominant muscles. A postexercise administration of ketone monoester together with glucose enhanced the glycogen repletion in murine slow-twitch fiber-dominant muscle but not in fast-twitch fiber-dominant muscle. The ketone monoester intake also elicited higher insulin levels in plasma and lower AMPK phosphorylation levels in soleus muscle during the postexercise phase.