What question did this study set out to answer?

To review the mechanisms by which cancer epigenetic dysregulation alters antitumor immunity and to evaluate the potential of epigenetic therapies to overcome immunotherapy resistance.

June 16, 2024Journal of Clinical InvestigationOpen Access

Epigenetic regulation of tumor immunity

View Full Paper

Ask AI

Bookmark

To review the mechanisms by which cancer epigenetic dysregulation alters antitumor immunity and to evaluate the potential of epigenetic therapies to overcome immunotherapy resistance.
Synthesized molecular and translational literature detailing epigenetic modifications that alter tumor-immune crosstalk.
Assessed preclinical and clinical evidence on epigenetic drugs combined with immune checkpoint inhibitors.
Epigenetic aberrations in tumor cells suppress immune cell infiltration, reshape the tumor microenvironment into an immunosuppressive state, and drive resistance to checkpoint blockade.
Pharmaceutically reversing epigenetic abnormalities restores tumor immunogenicity and synergistically enhances the efficacy of immune checkpoint inhibitors.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Narrative review uncovers epigenetic reprogramming of the tumor microenvironment in cancer cells, highlighting novel combination strategies to overcome immunotherapy resistance.

Cite This Study

Pang et al. (2024) studied this question.

synapsesocial.com/papers/6a70c7bf31a3df8243290535 https://doi.org/10.1172/jci178540

View Full Paper

Ask AI

Bookmark

Implication

Narrative review uncovers epigenetic reprogramming of the tumor microenvironment in cancer cells, highlighting novel combination strategies to overcome immunotherapy resistance.

Epigenetic regulation of tumor immunity

Key Points

Discussion

Implication

Cite This Study

Epigenetic regulation of tumor immunity

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider