Wedge Pressure vs Left Ventricular End-Diastolic Pressure for Pulmonary Hypertension Classification and Prognostication in Severe Aortic Stenosis

Figures

• 

  Figure 1. Definition of pulmonary hypertension (PH) and hemodynamic PH groups using (A) a mean pulmonary artery wedge pressure (mPAWP)-based vs (B) a left ventricular end-diastolic pressure (LVEDP)-based approach. For details, see text. CpcPH, combined pre- and postcapillary PH; DPG, diastolic pressure gradient; DPGLVEDP, DPG calculated as diastolic pulmonary artery pressure minus LVEDP (as opposed to DPG = diastolic pulmonary artery pressure – mPAWP, as used [A]); IpcPH, isolated postcapillary pulmonary hypertension; LVEDP, left ventricular end-diastolic pressure; mPAP, mean pulmonary artery pressure; mPAWP, mean pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; WU, Wood units.

• 

  Figure 2. (A) Bar graph showing the proportion of patients with pulmonary hypertension (PH; n = 140) with combined pre- and postcapillary PH (CpcPH), isolated postcapillary PH (IpcPH), and precapillary PH, according to the PH classification based on the mean pulmonary artery wedge pressure (mPAWP; left) vs the left ventricular end-diastolic pressure (LVEDP; right), and the reclassification steps. (B) Kaplan–Meier plots showing cumulative events (mortality) for patients with PH who were reclassified (differently classified by the mPAWP-based vs the LVEDP-based classification) and those who were not.

• 

  Figure 3. Kaplan–Meier plots showing cumulative events (post–aortic valve replacement mortality) for patients in different quartiles (Q) for (A) mean pulmonary artery wedge pressure (mPAWP) and (B) left ventricular end-diastolic pressure (LVEDP).

• 

  Figure 4. (A) Kaplan–Meier plots showing cumulative events (post–aortic valve replacement mortality) for patients in different quartiles (Q) for the difference between mean pulmonary artery wedge pressure (mPAWP) and left ventricular end-diastolic pressure (LVEDP; ΔmPAWP–LVEDP), and (B) receiver operator characteristics curve showing the areas under the curve (AUC; with 95% confidence intervals [CIs]) for mPAWP, LVEDP, and ΔmPAWP–LVEDP to predict mortality.