Population
Adult male rats (isolated ventricular myocytes)
Comparison
Castration for 16 weeks, with or without… vs Intact controls
Design
Preclinical
Follow-up
16 weeks
Authors
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Links androgens to rat myocyte calcium handling; leaves open translation to human sex differences in ventricular function.
Androgens regulate the functional expression of L-type calcium channels and Na/Ca exchangers in rat ventricular myocytes, suggesting a mechanism for sex differences in cardiac function.
Golden et al. (2003) studied this question.
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