Why the study?
Does carotid artery intima-media thickness predict the presence of coronary artery lesions independently of other risk factors?
Does carotid artery intima-media thickness predict the presence of coronary artery lesions independently of other risk factors?
Carotid intima-media thickness is an independent predictor of coronary artery lesions and may serve as a useful non-invasive clinical test for identifying significant coronary disease.
Carotid IMT was associated with CAD lesions; leaves open incremental value for screening beyond traditional risk factors.
The purpose of the present study was to examine whether intima-media thickness (IMT) predicts the presence of the coronary artery lesions independent of other risk factors including clinic blood pressure (BP), parameters of 24-h ambulatory BP monitoring, body mass index, serum cholesterol, and glucose levels. The study population consisted of 390 consecutive subjects who had recently undergone coronary arteriography; 51 subjects with no measurable lesions in their coronary arteries (control group) and 339 subjects with coronary artery lesions (coronary artery disease [CAD] group). Mean IMT of the common carotid artery (MCCA) and internal carotid artery (MICA) were significantly higher in subjects with CAD compare control subjects (P < .0001). Carotid IMT could predict the presence of coronary artery lesions independently of clinic or ambulatory BP values, BMI, serum cholesterol, and glucose levels (P < .01). Carotid IMT predicted the presence of significant coronary artery lesions with cutoff values 0.85 and 0.80 for MICA and MCCA, respectively. The IMT could be a clinical useful test for the presence of significant coronary artery lesions.
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Kotsis et al. (2005) studied this question.
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