What question did this study set out to answer?

To critically assess whether protein dynamical motions and non-equilibrium vibrational coupling contribute significantly to enzymatic rate acceleration beyond standard transition-state theory.

March 29, 2006Chemical Reviews

Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis

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To critically assess whether protein dynamical motions and non-equilibrium vibrational coupling contribute significantly to enzymatic rate acceleration beyond standard transition-state theory.
Evaluation of transition-state theory formulations and dynamical transmission coefficients in enzymatic versus solution reactions.
Analysis of free-energy landscapes and molecular dynamics simulations of enzymatic active sites and uncatalyzed reference reactions in solvent.
Dynamical transmission coefficients and non-statistical energy couplings in enzymes are qualitatively and quantitatively indistinguishable from those observed in corresponding uncatalyzed reactions in water.
Catalytic proficiencies of enzymes are comprehensively explained by electrostatic preorganization of the active site, which minimizes the reorganization energy and lowers the activation free-energy barrier.

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Implication

Critical review evaluates proposed dynamical effects in enzyme catalysis, indicating that catalytic power arises primarily from transition-state electrostatic stabilization rather than protein...

Cite This Study

Olsson et al. (2006) studied this question.

synapsesocial.com/papers/6a70c84a26770c2b8de0bfb2 https://doi.org/10.1021/cr040427e

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Implication

Critical review evaluates proposed dynamical effects in enzyme catalysis, indicating that catalytic power arises primarily from transition-state electrostatic stabilization rather than protein...

Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis

Key Points

Discussion

Implication

Cite This Study

Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis

Key Points

Discussion

Implication

Cite This Study

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