Why the study?
Does the relationship between carotid intima media thickness and plasma Lp-PLA2 mass differ between patients with type 2 diabetes and nondiabetic subjects?
Does the relationship between carotid intima media thickness and plasma Lp-PLA2 mass differ between patients with type 2 diabetes and nondiabetic subjects?
Plasma Lp-PLA2 mass is associated with subclinical atherosclerosis (IMT) in nondiabetic individuals but not in those with type 2 diabetes, questioning its utility as a biomarker in diabetic patients.
Questions Lp-PLA2 utility as atherosclerosis biomarker in diabetes; leaves open prospective validation in nondiabetics.
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Constantinides et al. (2011) studied this question.
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