Bispyrene-Conjugated 2′-O-Methyloligonucleotide as a Highly Specific RNA-Recognition Probe

In the living cell is where the authors hope to elucidate the structure of RNA by using their bispyrene-conjugated 2′-O-methyloligoribonucleotide (OMUpy2-I) fluorescence probe, to detect the hybridization with complementary RNA. The picture shows irradiated I) single-stranded OMUpy2-I, II) hybrid of OMUpy2-I with oligoRNA, and III) OMUpy2-I and oligoDNA.