Population
Primary human monocyte-derived macrophages and induced pluripotent stem cell-derived macrophages
Comparison
M1 activation and knockdown of splicing factor… vs Resting macrophages, M2 macrophages, and control
Design
Preclinical
Authors
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AS events during M1 activation may link to cardiometabolic risk; leaves open causal roles and therapeutic targeting.
Alternative splicing, particularly involving factors like CELF1, plays a significant role in regulating human macrophage inflammatory phenotypes and may offer novel targets for cardiometabolic diseases.
Lin et al. (2016) studied this question.
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