February 1, 1988HypertensionOpen Access

The ventrolateral medulla. A new site of action of the renin-angiotensin system.

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Population

Preclinical animal model (species not specified in abstract)

Comparison

Topical application of angiotensin I… vs Baseline state

Design

Preclinical

Authors

SASophia AndreattaThe Ohio State University DADavid B. AverillGeisinger Commonwealth School of Medicine RSRobson A.S. SantosGeneral Cardiology

Discussion

Member takes

Implication

Supports local brainstem RAS in vasomotor control; hypothesis-generating for human hypertension therapies.

Structured PICO

Population

Preclinical animal model (species not specified in abstract)

Intervention

Topical application of angiotensin I (100 pmol), angiotensin II (100 pmol), [Sar1, Thr8]Ang II (13 nmol), and MK 422 to the glycine-sensitive area of the ventral medullary surface

Comparator

Baseline state

Outcome

Change in blood pressuresurrogate

Components of the renin-angiotensin system exist in the ventrolateral medulla and can modulate vasomotor outflow and blood pressure.

Cite This Study

Andreatta et al. (1988) studied this question.

synapsesocial.com/papers/6a70c9496c240de38cdbefb2 https://doi.org/10.1161/01.hyp.11.2_pt_2.i163

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The ventrolateral medulla. A new site of action of the renin-angiotensin system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The ventrolateral medulla. A new site of action of the renin-angiotensin system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider