Why the study?
Does a prolonged detection interval (NID 30/40) reduce ICD therapies delivered to terminate spontaneous VT in patients with Class I-IIA indication for ICD therapy?
Population
Patients with Class I-IIA indication for ICD therapy, regardless of cardiac resynchronization capabilities
Comparison
Prolonged detection interval for life… vs Standard detection interval (NID 18/24)
Design
RCT, randomized, parallel trial with 2 arms
Authors
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Tests whether prolonged detection safely cuts ICD therapies; RCT extends prior data to broad indicated population.
Does a prolonged detection interval (NID 30/40) reduce ICD therapies delivered to terminate spontaneous VT in patients with Class I-IIA indication for ICD therapy?
The ADVANCE III trial is designed to evaluate whether a prolonged detection interval can safely reduce unnecessary ICD therapies for fast ventricular tachyarrhythmias in a general ICD patient cohort.
SCHWAB et al. (2009) studied this question.
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