January 1, 2007Pacing and Clinical Electrophysiology
A Comparison of ICD Implantations in the United States Versus Italy
Why the study?
Are there differences in ICD implantation indications and device types between the United States and Italy?
Population
11,038 patients undergoing initial implantable cardioverter defibrillator implantations
Comparison
ICD implantation in the United States vs ICD implantation in Italy (IIR registry)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Regional variations in ICD use caution against pooling or generalizing trial data across continents; leaves open whether outcomes differ by indication thresholds.
Structured PICO
Are there differences in ICD implantation indications and device types between the United States and Italy?
P
Population
11,038 patients undergoing initial implantable cardioverter defibrillator (ICD) implantations (4,547 in the US ACT registry and 6,491 in the Italian IIR registry)
I
Intervention
ICD implantation in the United States (ACT registry)
C
Comparator
ICD implantation in Italy (IIR registry)
O
Outcome
Device indications (primary vs secondary prevention) and device types (single, dual chamber, or cardiac resynchronization)
There are significant transcontinental differences in ICD implantation patterns between the US and Italy, with the US favoring primary prevention and dual-chamber devices, and Italy favoring secondary prevention and CRT-D.
Cite This Study
Greenberg et al. (2007) studied this question.