What question did this study set out to answer?

To identify molecular subgroups in small cell lung cancer (SCLC) and characterize biomarkers that distinguish chemo-sensitive from chemo-refractory disease prior to treatment.

August 28, 2017OncotargetOpen Access

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

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Authors

KMKaren McCollUniversity Hospitals Seidman Cancer Center GWGary WildeyUniversity Hospitals Seidman Cancer Center NSNneha SakreStanford University

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Implication

Molecular profiling study reveals reciprocal INSM1 and YAP1 expression defines subtypes in small cell lung cancer, suggesting biomarkers for chemo-refractory disease.

Key Points

To identify molecular subgroups in small cell lung cancer (SCLC) and characterize biomarkers that distinguish chemo-sensitive from chemo-refractory disease prior to treatment.
Analyzed gene expression profiles across SCLC cell lines and primary patient tumor specimens.
Evaluated the relationship between INSM1, YAP1, and RB1 status with in vitro chemotherapy sensitivity, CDK4/6 inhibitor responsiveness, and patient survival outcomes.
INSM1 expression characterized the majority of SCLC tumors and correlated with increased progression-free survival in patients and chemo-sensitivity in cell lines.
YAP1 expression occurred in a minority of SCLC tumors, functioned downstream of RB1, and associated with reduced chemotherapy sensitivity in cell lines.
Wild-type RB1 status, serving as a surrogate marker for YAP1 expression, was prognostic for decreased patient survival, conferred chemo-refractoriness, and sensitized cell lines to CDK4/6 inhibitors.

Cite This Study

McColl et al. (2017) studied this question.

synapsesocial.com/papers/6a70cc7575498292b70a447f https://doi.org/10.18632/oncotarget.20572

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Implication

Molecular profiling study reveals reciprocal INSM1 and YAP1 expression defines subtypes in small cell lung cancer, suggesting biomarkers for chemo-refractory disease.

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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