Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 28, 2003Journal of VirologyOpen Access

In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells

View Full Paper
Ask AI
Bookmark
Share

Authors

AJAndreas JekleRapt Therapeutics (United States)OKOliver T. KepplerDepartment of VirologyErik De ClercqErik De ClercqRega Institute for Medical Research

Discussion

Loading...

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Jekle et al. (2003) studied this question.

synapsesocial.com/papers/6a70ce7f26a7f98052dd43b7https://doi.org/10.1128/jvi.77.10.5846-5854.2003
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers2000 · 143 citations
  2. 2Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression1996 · 501 citations
  3. 3Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status2001 · 42 citations
  4. 4The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling1999 · 83 citations
  5. 5Critical Contribution of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) to Apoptosis of Human Cd4+T Cells in HIV-1–Infected Hu-Pbl-Nod-Scid Mice2001 · 132 citations