September 22, 2009Hypertension

Leptin Impairs Cardiovagal Baroreflex Function at the Level of the Solitary Tract Nucleus

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Population

Urethane/chloralose-anesthetized Sprague-Dawley rats and transgenic ASrAOGEN rats

Comparison

Solitary tract nucleus microinjection of leptin vs Baseline/control state

Design

Preclinical

Authors

AAAmy C. ArnoldGeneral Cardiology HSHossam A. ShaltoutWake Forest University PGPatricia E. GallagherWake Forest University

Discussion

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Implication

May implicate central leptin in obesity hypertension; hypothesis-generating for baroreflex-targeted interventions pending human data.

Structured PICO

Population

Urethane/chloralose-anesthetized Sprague-Dawley rats and transgenic ASrAOGEN rats (with low brain angiotensinogen)

Intervention

Solitary tract nucleus microinjection of leptin (144 fmol/60 nL or 500 fmol)

Comparator

Baseline/control state

Outcome

Baroreflex sensitivity for bradycardia in response to increases in pressuresurrogate

Exogenous leptin in the solitary tract nucleus impairs baroreflex sensitivity for bradycardia, suggesting a central mechanism contributing to obesity-related hypertension.

Cite This Study

Arnold et al. (2009) studied this question.

synapsesocial.com/papers/6a70d15cf44fa9f079de86c8 https://doi.org/10.1161/hypertensionaha.109.138065

View Full Paper

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Leptin Impairs Cardiovagal Baroreflex Function at the Level of the Solitary Tract Nucleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Leptin Impairs Cardiovagal Baroreflex Function at the Level of the Solitary Tract Nucleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider