Trajectory of mean platelet volume changes after aneurysmal subarachnoid hemorrhage in patients with or without delayed cerebral ischemia

Figures

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  Figure 1. Mean platelet volume (MPV) as a function of time from admission to collection. The raw individual trajectories are described in the panel a; each dot from each patient is connected to the following sample by a solid line. The modeled MVP trajectories using a linear mixed-effects regression are shown as solid lines in panel b, the dots represent individual values. The patients who presented with a delayed cerebral ischemia (DCI +) are in red while those without DCI (DCI -) are in blue. The p-value refers to the significant difference between MPV trajectories of patients with DCI and those without, with an estimate of 0.02 (95%CI 0.01, 0,04, p = 0.009). Time to collection represents the time of sampling since admission.

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  Figure 2. Overall trajectories of mean platelet volume (MVP) to platelet count (PLT) ratio (MPV/PLT) as a function of sampling time since admission. The solid lines represent the modeled trajectories after applying a linear mixed effects regression and the dots correspond to individual values. The patients who presented with a delayed cerebral ischemia (DCI +) are in red while those without DCI (DCI -) are in blue. Time to collection represents the time of sampling since admission.

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  Figure 3. Individual trajectories of the mean platelet volume (MPV) to platelet count (MPV/PLT) ratio as a function of sampling time from admission, according to the modified Fischer score (mFS). The raw individual MPV/PLT trajectories are shown for patients with an mFS > 2 (i.e. high amount of blood; the left panel) and for patients with an mFS < 3 (lower amount of blood; right panel). The patients who presented with a delayed cerebral ischemia (DCI+) are in red while those without DCI (DCI -) are in blue. The p-value refers to the significant difference between the MPV/PLT trajectories of patients with DCI and those without when considering only patients with an mFS < 3 (-0.59, 95%CI -0.94, -0.23, p = 0.001). Time to collection represents the time of sampling since admission.