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July 1, 1966Circulation ResearchOpen Access

Correlation of Visco-elastic Properties of Large Arteries with Microscopic Structure

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Population

14 regions of the aorta and 3 regions of the pulmonary artery of dogs

Design

Preclinical

Authors

JAJulia T. ApterNorthwestern UniversityMRMurray RabinowitzNorthwestern UniversityDCDOROTHY H. CUMMINGSUniversity of Chicago

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Implication

Highlights muscle and elastin roles in canine arterial viscoelasticity; extends biomechanical models but leaves open human translation.

Key Points

  • To determine how specific microscopic structural components of large artery walls govern their viscoelastic and stress-relaxation behaviors under rapid circumferential stretch.
  • Subjected media segments from 14 aortic regions and 3 pulmonary artery regions in dogs to a 20-millisecond step-function circumferential stretch while recording tension curves over 2 seconds.
  • Derived viscous, series-elastic, and parallel-elastic constants using a mathematical model fitted to the observed stress-relaxation response.
  • Quantified wall constituents using hydroxyproline fractions for collagen and elastin, lamellar histology, nonfibrous nitrogen content, cell counts, and contractility assays for smooth muscle.
  • Viscous and series-elastic constants correlated positively with smooth muscle content and showed marked increases during tonic smooth muscle contraction.
  • Parallel-elastic constants were significantly higher in arterial segments with elevated elastin content and during muscle contraction.
  • Parallel-elastic behavior operated independently of total collagen content under the moderate tension levels evaluated.

Structured PICO

P
Population
14 regions of the aorta and 3 regions of the pulmonary artery of dogs
I
Intervention
Step-function circumferential stretch taking 20 msec to complete
O
Outcome
Correlation of viscous, series-elastic, and parallel-elastic constants with microscopic structure (collagen, elastin, muscle)surrogate

This preclinical study demonstrates that the visco-elastic properties of large arteries correlate specifically with their microscopic content of muscle and elastin, but not collagen at moderate tensions.

Cite This Study

Apter et al. (1966) studied this question.

synapsesocial.com/papers/6a70d356f44fa9f079de89c2https://doi.org/10.1161/01.res.19.1.104
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurements on the Elasticity and Damping of Isolated Aortic Strips of the Dog1955 · 59 citations
  2. 2Relation of Structure to Function of the Tissues of the Wall of Blood Vessels1954 · 801 citations