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Ogon, an important Chinese crude drug (the dried roots of Scutellaria baicalensis GEORGI), is listed in ancient Chinese herbals and is used in the treatment of a number of diseases. Ether extract of this crude drug showed a relatively marked antibacterial activity against Gram-positive bacteria. Fractionation of the extract accompanied by the bioassay led to the isolation of active principles. The structure of one of these was elucidated as 2(S), 2′, 5, 6′, 7-tetrahydroxyflavanone.
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Kubo et al. (1981) studied this question.
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