May 1, 1997Journal of Biological ChemistryOpen Access

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

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Population

Rat aortic vascular smooth muscle cells

Design

Preclinical

Authors

MAMohammad AliGeorgia Institute of Technology BSBernhard SchiefferInterventional Cardiology PDPatrice DelafontaineInterventional / Structural Cardiology

Discussion

Member takes

Implication

Does not yet alter clinical practice; leaves open convergent Ang II-IGF-I signaling via IRS-1/PTP-1D in VSMCs for further study.

Structured PICO

Population

Rat aortic vascular smooth muscle cells

Intervention

Angiotensin II (10^-7 M) and insulin-like growth factor I (IGF I, 20 ng/ml)

Outcome

Tyrosine phosphorylation of IRS-1 and PTP-1D, and PTP-1D phosphatase activitysurrogate

Angiotensin II and IGF I stimulate a convergent intracellular signaling cascade involving tyrosine phosphorylation of IRS-1 and PTP-1D in vascular smooth muscle cells.

Cite This Study

Ali et al. (1997) studied this question.

synapsesocial.com/papers/6a70d46e6ceb2bbd16e0016c https://doi.org/10.1074/jbc.272.19.12373

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Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider