Why the study?
Decreased efficacy of edoxaban versus warfarin for stroke and systemic embolism prevention had been reported in AF patients with CrCl > 95 mL/min, prompting clarification of safety and efficacy across various CrCl levels.
Does edoxaban improve efficacy and safety compared to warfarin in atrial fibrillation patients across different levels of renal function?
Population
28,065 AF patients across various CrCl levels
Comparison
Edoxaban vs warfarin
Authors
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Caution against edoxaban in AF with CrCl >95 mL/min; confirms reduced efficacy versus warfarin and refines NOAC selection.
Does edoxaban improve efficacy and safety compared to warfarin in atrial fibrillation patients across different levels of renal function?
Edoxaban demonstrates comparable efficacy and superior or comparable safety (reduced bleeding) compared to warfarin across various levels of renal function in patients with atrial fibrillation, including those with supranormal renal function (CrCl > 95 mL/min).
Wang et al. (2023) studied this question.
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