Why the study?
Can a limited sampling model accurately estimate the AUC of doxorubicin and epirubicin from maximum plasma concentrations?
Population
Patients with lymphoma, median age 46.5 years
Design
Other
Authors
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May support limited epirubicin AUC sampling; leaves open prospective validation before clinical adoption.
Can a limited sampling model accurately estimate the AUC of doxorubicin and epirubicin from maximum plasma concentrations?
A limited sampling model using maximum plasma concentration at the end of infusion can accurately estimate the AUC of doxorubicin and epirubicin.
Staffan Eksborg (1990) studied this question.
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