What question did this study set out to answer?

To examine the effects of targeted growth hormone receptor and binding protein gene disruption on body growth, circulating IGF-I and binding proteins, and overall lifespan in a mouse model of Laron syndrome.

July 1, 2000EndocrinologyOpen Access

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

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To examine the effects of targeted growth hormone receptor and binding protein gene disruption on body growth, circulating IGF-I and binding proteins, and overall lifespan in a mouse model of Laron syndrome.
Evaluated homozygous (-/-), heterozygous (+/-), and wild-type (+/+) mice with targeted disruption of the GHR/BP gene.
Assessed body size up to 1.5 years of age and measured circulating concentrations of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3, and IGFBP-4 across the lifespan.
Homozygous (-/-) mice displayed significantly smaller body size than wild-type (+/+) and heterozygous (+/-) controls, an effect persisting up to 1.5 years of age.
Circulating IGF-I and IGFBP-3 levels were significantly and chronically reduced in homozygous (-/-) mice, whereas IGFBP-1, IGFBP-2, and IGFBP-4 levels were unchanged.
Homozygous (-/-) mice lived significantly longer than both wild-type (+/+) and heterozygous (+/-) mice.

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Implication

Animal study reveals reduced growth, altered IGF-I signaling, and extended lifespan in GHR/BP gene-disrupted mice, indicating that deficient growth hormone signaling enhances longevity.

Cite This Study

Coschigano et al. (2000) studied this question.

synapsesocial.com/papers/6a70d68a35aa2c282ce229f0 https://doi.org/10.1210/endo.141.7.7586

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Implication

Animal study reveals reduced growth, altered IGF-I signaling, and extended lifespan in GHR/BP gene-disrupted mice, indicating that deficient growth hormone signaling enhances longevity.

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

Key Points

Discussion

Implication

Cite This Study

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

Key Points

Discussion

Implication

Cite This Study

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