Clozapine titration can induce paroxysmal supraventricular tachycardia, highlighting the need for slow titration and cardiac monitoring in patients with treatment-resistant schizophrenia.
Clozapine is considered to be more effective than other antipsychotic drugs for treating treatmentresistant schizophrenia. However, side effects of clozapine include agranulocytosis and, less commonly, cardiovascular disease, which is occasionally fatal. We describe a 56-year-old woman who developed clozapine-related paroxysmal supraventricular tachycardia during clozapine dose titration and had a recurrence despite being treated with verapamil. For treatment-resistant schizophrenia, a slow titration of the clozapine dose is necessary, and potential cardiac side-effects should be monitored.
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Kim et al. (2018) studied this question.
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