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December 4, 1969New England Journal of Medicine

A Familial Defect in Platelet Function Associated with Impaired Release of Adenosine Diphosphate

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Population

Six affected members of a family with a primary disorder of hemostasis characterized by a familial defect in…

Design

Case_series

Authors

HWHarvey J. WeissColumbia UniversityPCPaul A. ChervenickMoffitt Cancer CenterRZRalph ZaluskyMount Sinai Beth Israel

Discussion

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Implication

Describes a rare familial platelet storage pool defect; hypothesis-generating and requires confirmation before clinical or genetic inferences.

Structured PICO

P
Population
Six affected members of a family with a primary disorder of hemostasis characterized by a familial defect in platelet function
O
Outcome
Platelet function (aggregation, ADP release, bleeding time, ATP/ADP content)surrogate

Identifies a familial autosomal dominant platelet function defect characterized by impaired ADP release and reduced platelet ATP/ADP content.

Cite This Study

Weiss et al. (1969) studied this question.

synapsesocial.com/papers/6a70d7d9f44fa9f079de90d9https://doi.org/10.1056/nejm196912042812303
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Dysfunction — Differentiation of a Newly Recognized Primary Type from That Produced by Aspirin1969 · 49 citations
  2. 2Platelet Counts with the Coulter Counter1965 · 343 citations
  3. 3Antihaemophilic Globulin (AHG) in Multiple Myeloma and Macroglobulinaemia1968 · 18 citations