Prostaglandins E1, A1, and F2 have species-dependent chronotropic effects on isolated mammalian cardiac tissue, with direct chronotropic effects in cats but not dogs, and no direct inotropic effects in either.
Species variation in prostaglandin effects cautions against human extrapolation; leaves open direct cardiac actions in clinical settings.
This study indicates that the chronotropic and inotropic effects of PG on isolated cardiac muscle are species dependent. While a direct chronotropic effect was observed on the atrial tissue of the cat, the PG appear to be devoid of direct chronotropic effects on canine cardiac tissue and of direct inotropic effects in both feline and canine cardiac tissue.
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Su et al. (1973) studied this question.
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