June 10, 2011PLoS ONEOpen Access

ACE2 Improves Right Ventricular Function in a Pressure Overload Model

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Why the study?

Does rhACE2 improve right ventricular function in a mouse pressure overload model?

Population

Pulmonary artery banded mice (mouse right ventricular load-stress model of early heart failure)

Design

Preclinical

Authors

JJJennifer JohnsonRutgers, The State University of New Jersey JWJames WestVanderbilt University KMKaren B. MaynardPulmonary and Critical Care Associates

Discussion

Member takes

Implication

Supports rhACE2 exploration in RV failure; leaves open translation from this mouse model to clinical use.

Structured PICO

Does rhACE2 improve right ventricular function in a mouse pressure overload model?

Population

Pulmonary artery banded mice (mouse right ventricular load-stress model of early heart failure)

Intervention

Recombinant human angiotensin-converting enzyme 2 (rhACE2) administered at 1.8 mg/kg/day

Outcome

Right ventricular systolic and diastolic function (measured by in vivo hemodynamics)surrogate

In a mouse model of right ventricular pressure overload, rhACE2 improved RV hemodynamics and reduced hypertrophy, suggesting potential as a novel therapy for RV failure.

Cite This Study

Johnson et al. (2011) studied this question.

synapsesocial.com/papers/6a70d91b84cc45bb7bdfd717 https://doi.org/10.1371/journal.pone.0020828

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ACE2 Improves Right Ventricular Function in a Pressure Overload Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ACE2 Improves Right Ventricular Function in a Pressure Overload Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider