Why the study?
Does a continuous infusion regimen of tranexamic acid reduce fibrinolysis and postoperative blood loss in patients undergoing cardiac operations compared to bolus dosing?
Does a continuous infusion regimen of tranexamic acid reduce fibrinolysis and postoperative blood loss in patients undergoing cardiac operations compared to bolus dosing?
A continuous infusion of tranexamic acid combined with a bolus at the start of cardiopulmonary bypass is more effective at reducing fibrinolysis and postoperative blood loss than a bolus at the end of bypass.
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Findings support randomized trials of continuous tranexamic acid infusion in cardiac surgery; should not yet alter clinical practice.
Matsuzaki et al. (1999) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: