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February 3, 2019Diabetes and Vascular Disease ResearchOpen Access

Volumes of coronary plaque disease in relation to body mass index, waist circumference, truncal fat mass and epicardial adipose tissue in patients with type 2 diabetes mellitus and controls

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Why the study?

Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution, but the association across various obesity and fat measures was unclear.

Are anthropometric measures of obesity associated with coronary plaque volumes in asymptomatic patients with type 2 diabetes mellitus and controls?

Population

44 patients with type 2 diabetes mellitus and 59 matched controls

Comparison

Associations across BMI, waist circumference, truncal fat mass, and epicardial adipose tissue

Design

Matched cross-sectional study

Authors

SGSøren GullaksenKFKristian Løkke FunckELEsben Laugesen

Discussion

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Member takes

Overview

BMI and waist circumference associate with plaque volumes in asymptomatic T2D; leaves open whether regional fat drives progression.

Structured PICO

Are anthropometric measures of obesity associated with coronary plaque volumes in asymptomatic patients with type 2 diabetes mellitus and controls?

P
Population
103 asymptomatic individuals (44 with type 2 diabetes mellitus and 59 matched controls), mean age 64.4 vs 61.8, 50% vs 47% male.
O
Outcome
Coronary plaque volumes (total, calcified, non-calcified and low-density non-calcified) assessed by coronary computed tomography angiographysurrogate

Body mass index, but not regional fat distribution measures like epicardial adipose tissue, is independently associated with low-density non-calcified coronary plaque volume in both diabetic and non-diabetic individuals.

Cite This Study

Gullaksen et al. (2019) studied this question.

synapsesocial.com/papers/6a70da5f6ceb2bbd16e004a4https://doi.org/10.1177/1479164119825761
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate2017 · 49 citations
  2. 2Increased high-risk coronary plaque burden is associated with arterial stiffness in patients with type 2 diabetes without clinical signs of coronary artery disease2017 · 20 citations
  3. 3Epicardial fat and vascular risk2013 · 77 citations
  4. 4Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes2012 · 43 citations
  5. 5Effects of Statins on Serum Inflammatory Markers: The U.S. National Health and Nutrition Examination Survey 1999-20042010 · 35 citations