April 11, 2016Angiology
Assessment of Subclinical Atherosclerosis by Carotid Intima–Media Thickness and Epicardial Adipose Tissue Thickness in Prediabetes
Why the study?
Are epicardial fat thickness and carotid intima-media thickness increased in patients with prediabetes compared to controls?
Population
246 patients, including 162 with prediabetes and 84 controls.
Comparison
Prediabetes vs Controls without prediabetes
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Prediabetes may associate with greater EFT and cIMT; leaves open their value for CVD risk stratification.
Structured PICO
Are epicardial fat thickness and carotid intima-media thickness increased in patients with prediabetes compared to controls?
P
Population
246 patients, including 162 with prediabetes (defined by American Diabetes Association criteria: impaired fasting glucose, impaired glucose tolerance, or both) and 84 controls.
I
Intervention
Prediabetes (impaired fasting glucose, impaired glucose tolerance, or both)
C
Comparator
Controls without prediabetes
O
Outcome
Carotid intima-media thickness (cIMT) and epicardial fat thickness (EFT)surrogate
Patients with prediabetes, particularly those with impaired glucose tolerance, exhibit increased cIMT and EFT, indicating a higher burden of early subclinical atherosclerosis.
Limitations
- Small sample size
- Lack of long-term prospective follow-up
Cite This Study
Altın et al. (2016) studied this question.