In children and adolescents with Type 2 Diabetes, RBP4 levels correlate with the severity of hepatic steatosis, suggesting its potential utility as a non-invasive serum biomarker.
RBP4 evaluation in adolescent T2D is hypothesis-generating; leaves open its utility for IR or steatosis risk stratification.
Type 4 retinol binding protein (RBP4) is a novel adipocytokine that has been related with insulin resistance (IR). In pediatric population, RBP4 levels are higher in obese subjects compared with lean subjects. In adults with type 2 diabetes (T2D) a positive correlation has been found between RBP4 levels and hepatic steatosis (HS). There is scarce information on RBP4 levels in children and adolescents with T2D. The aim of our study was to evaluate RBP4 levels in T2D adolescents and its association to HS.
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Bravo et al. (2015) studied this question.
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