Cross-Sectional (n=75)
No
Absolute Event Rate: 90.09% vs 70.06%
p-value: p=<0.001
RBP-4 may link insulin resistance to postmenopausal CVD; hypothesis-generating, prospective studies needed before any clinical role.
Background: Retinol binding protein-4 (RBP-4) is a newly discovered adipokine, which is mainly secreted by liver and originally known to be the only specific transport protein for vitamin A in the circulation. Recently, RBP-4 is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes mellitus (T2DM). It is well known that there is a higher prevalence of cardiovascular risk factors and metabolic syndrome (MS) in postmenopausal women. Postmenopausal status is believed to be a risk factor for IR in women. IR has a causal role in the development of T2DM. Even in the absence of hyperglycemia or diabetes, IR contributes to an increased risk of cardiovascular disease (CVD).
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El-Kaream et al. (2015) conducted a cross-sectional in Cardiovascular disease and insulin resistance (n=75). Cardiovascular disease in postmenopausal women vs. Healthy postmenopausal women was evaluated on Plasma RBP-4 concentration (mg/L) (p=<0.001).
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