May 1, 1997AJP Heart and Circulatory Physiology

Involvement of AT2 receptors at NRVL in tonic baroreflex suppression by endogenous angiotensins

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Population

Adult male Sprague-Dawley rats anesthetized and maintained with pentobarbital sodium

Design

Preclinical

Authors

KLKai-Yu LinNational Taiwan University JCJeng Yie ChanGarvan Institute of Medical Research SCS. H. ChanChina Pharmaceutical University

Discussion

Member takes

Implication

AT2 modulation of baroreflex is hypothesis-generating in animals; leaves open any human therapeutic relevance pending clinical studies.

Structured PICO

Population

Adult male Sprague-Dawley rats anesthetized and maintained with pentobarbital sodium

Intervention

Bilateral microinjection into the rostral nucleus reticularis ventrolateralis (NRVL) of ANG II or ANG III (10, 20, or 40 pmol), and their antagonists ([Sar1, Ile8]ANG II, [Ile7]ANG III, losartan, PD-123319)

Outcome

Baroreceptor reflex (BRR) response to transient hypertension induced by phenylephrine (5 micrograms/kg i.v.)surrogate

Endogenous ANG II and ANG III exert a tonic inhibitory modulation on the baroreceptor reflex response by acting selectively on AT2 receptors at the NRVL.

Cite This Study

Lin et al. (1997) studied this question.

synapsesocial.com/papers/6a70dbcda528af2d65c3c8a8 https://doi.org/10.1152/ajpheart.1997.272.5.h2204

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Involvement of AT2 receptors at NRVL in tonic baroreflex suppression by endogenous angiotensins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of AT2 receptors at NRVL in tonic baroreflex suppression by endogenous angiotensins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider