June 1, 1975Acta Physiologica Scandinavica
Prostaglandin Endoperoxides IX. Characterization of Rabbit Aorta Contracting Substance (RCS) from Guinea Pig Lung and Human Platelets
Population
Isolated rabbit aorta, guinea pig lung, and human blood platelets
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data separate unstable RCS from endoperoxides; leaves open its identity and relevance to human disease.
Structured PICO
P
Population
Isolated rabbit aorta, guinea pig lung, and human blood platelets
I
Intervention
Arachidonic acid perfusion (guinea pig lung), thrombin addition (human platelets), and pure prostaglandins G2 and H2
O
Outcome
Contractile response of the isolated rabbit aorta and characterization of the contracting substancesurrogate
The study demonstrates that the major component of rabbit aorta contracting substance (RCS) is a highly unstable material distinct from prostaglandin endoperoxides.
Cite This Study
Svensson et al. (1975) studied this question.