Intravenous isoprenaline infusion in rats provides a dose-dependent model for inducing myocardial necrosis, particularly in the subendocardium and apex.
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Offers a reproducible rat model of regional myocardial necrosis; leaves open translation to human disease.
Intravenous infusion of isoprenaline in doses of 2,20,200,2000 μg/kg per min over 20 min into heparinized Wistar rats results in myocardial necroses and a rise in SGPT activity, erythrocyte sedimentation rate and leucocytosis. A quantitative method for estimation of intensity and distribution of myocardial necrotic foci is described. The intensity of myocardial lesions is observed linearly related to the infused isoprenaline at 2, 20 and 200 μg/kg per min. Damaged areas are mainly found in subendocardial and apical regions of left ventricle.
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Gryglewski et al. (1971) studied this question.
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