Key result
Isoprenaline infusion increased total myocardial K+ influx from 414 to 1086 mumol 100 g-1 min-1 in the in-situ beating pig heart.
Why the study?
Does isoprenaline increase total myocardial K+ influx in an in-situ beating porcine heart?
Population
Six anaesthetized, open-chest pigs
Comparison
Intravenous isoprenaline infusion vs Baseline (before isoprenaline infusion)
Design
Preclinical
Authors
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Supports mechanistic studies of beta-adrenergic K+ handling in intact hearts; leaves open human translation.
Does isoprenaline increase total myocardial K+ influx in an in-situ beating porcine heart?
Absolute Event Rate: 1086% vs 414%
Beta-adrenoceptor stimulation with isoprenaline significantly augments total myocardial K+ influx through both ouabain-sensitive and ouabain-insensitive pathways in the in-situ beating pig heart.
ANDERSEN et al. (1990) studied this question. Isoprenaline vs. Baseline (before infusion) was evaluated on Total K+ influx. Isoprenaline infusion increased total myocardial K+ influx from 414 to 1086 mumol 100 g-1 min-1 in the in-situ beating pig heart.
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