A Mammalian Transient Type K+ Channel, Rat Kv1.4, Has Two Potential Domains That Could Produce Rapid Inactivation

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Population

Xenopus oocytes expressing rat Kv1.4 mutants

Design

Preclinical

Authors

Discussion

Animal data on Kv1.4 gating warrant caution before human extrapolation; leaves open domain conservation in cardiac channels.

Population

Xenopus oocytes expressing rat Kv1.4 mutants

Intervention

Mutations in the amino terminus of rat Kv1.4 (residues 1-37 and 40-68)

Outcome

Function as an inactivation gate (rapid inactivation of voltage-dependent K+ channels)surrogate

The rat Kv1.4 channel possesses two independent domains in its amino terminus (residues 1-37 and 40-68) that can produce rapid inactivation.

Kondoh et al. (1997) studied this question.

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