October 12, 2001Circulation ResearchOpen Access

Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca 2+ Channels

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Population

Freshly isolated and cultured vascular myocytes

Design

Preclinical

Authors

NMNathalie MacrezCentre National de la Recherche Scientifique CMC. MironneauCentre National de la Recherche Scientifique VCValérie CarricaburuBoston Biomedical Research Institute

Discussion

Member takes

Implication

PI3Kβ-selective targeting merits exploration in vascular Ca2+ regulation; leaves open translation beyond animal models.

Structured PICO

Population

Freshly isolated and cultured vascular myocytes

Intervention

Purified recombinant PI3Ks (alpha, beta, delta, gamma), angiotensin II, Gbetagamma, platelet-derived growth factor (PDGF)-BB, and phosphotyrosyl peptide

Outcome

Peak Ca(2+) channel current densitysurrogate

Different isoforms of PI3K selectively regulate physiological increases of Ca2+ influx in vascular myocytes stimulated by vasoconstrictors or growth factors.

Cite This Study

Macrez et al. (2001) studied this question.

synapsesocial.com/papers/6a70df09e5469ee92be18b7a https://doi.org/10.1161/hh2001.097864

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Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca 2+ Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca 2+ Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider