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December 12, 2003Acta Anaesthesiologica Scandinavica

The effect of carbon dioxide, respiratory rate and tidal volume on human heart rate variability

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Why the study?

Do changes in PaCO2, tidal volume, and respiratory rate affect heart rate variability in conscious and anesthetized individuals?

Population

47 individuals comprising 22 healthy volunteers and 25 mechanically ventilated anesthetized patients

Comparison

Modulation of PaCO2, tidal volume, and… vs Baseline physiological state without added CO2…

Design

Other

Authors

MPM. PöyhönenSSSakari SyväojaJHJuha Hartikainen

Discussion

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Overview

Respiratory parameters warrant control during HRV assessment in awake patients; leaves open anesthesia-specific effects and requires prospective validation.

Structured PICO

Do changes in PaCO2, tidal volume, and respiratory rate affect heart rate variability in conscious and anesthetized individuals?

P
Population
47 individuals comprising 22 healthy volunteers and 25 mechanically ventilated anesthetized patients
I
Intervention
Modulation of PaCO2 (adding CO2 to inspiratory gas), tidal volume, and respiratory rate during spontaneous and mechanical ventilation
C
Comparator
Baseline physiological state without added CO2 or altered respiratory parameters
O
Outcome
Heart rate variability (high frequency and low frequency components)surrogate

Respiratory parameters and PaCO2 significantly modulate heart rate variability in conscious individuals, highlighting the need to control these variables during HRV assessment.

Cite This Study

Pöyhönen et al. (2003) studied this question.

synapsesocial.com/papers/6a70dfefe36a167817e2b35ehttps://doi.org/10.1111/j.1399-6576.2004.00272.x
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Also Consider

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  1. 1Important influence of respiration on human R-R interval power spectra is largely ignored1993 · 772 citations
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