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March 1, 2000AJP Cell Physiology

Inhibition of CaM kinase II activation and force maintenance by KN-93 in arterial smooth muscle

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Population

Intact arterial smooth muscle

Comparison

KN-93 (CaM kinase II inhibitor) pretreatment vs No KN-93 pretreatment

Design

Preclinical

Authors

ARAnikó RokolyaUniversity of CalgaryHSHarold A. SingerAlbany Medical Center Hospital

Discussion

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Implication

KN-93 attenuates CaMKII-dependent force in animal arteries; hypothesis-generating for CaMKII in human vascular tone.

Structured PICO

P
Population
Intact arterial smooth muscle
I
Intervention
KN-93 (CaM kinase II inhibitor) pretreatment
C
Comparator
No KN-93 pretreatment (response to histamine, KCl, or PDBu alone)
O
Outcome
CaM kinase II activation, phosphorylation of myosin regulatory light chains (MLC(20)), and forcesurrogate

KN-93 inhibits CaM kinase II activation and force maintenance in arterial smooth muscle, highlighting the role of CaM kinase II in regulating tonic contractile responses.

Cite This Study

Rokolya et al. (2000) studied this question.

synapsesocial.com/papers/6a70e05ef44fa9f079de9b34https://doi.org/10.1152/ajpcell.2000.278.3.c537
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New isoforms of Ca2+/calmodulin-dependent protein kinase II in smooth muscle1994 · 26 citations
  2. 2Calcium/Calmodulin-dependent Protein Kinase IIα Mediates Activation of Mitogen-activated Protein Kinase and Cytosolic Phospholipase A2 in Norepinephrine-induced Arachidonic Acid Release in Rabbit Aortic Smooth Muscle Cells1996 · 158 citations
  3. 3Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase.1990 · 87 citations
  4. 4What is special about smooth muscle? The significance of covalent crossbridge regulation1994 · 141 citations
  5. 5Role of Calcium/Calmodulin-Dependent Protein Kinase II in the Regulation of Vascular Smooth Muscle Cell Migration1995 · 116 citations